Multifunctional drug nanosystems: A summary of recent researches at IMS/VAST
The
main task of nanomedicine is to fabricate, normally by chemical
engineering, nanoscale systems that can play various functions of both
diagnosis and treatment. This report aims to present some researches,
carried out by the Laboratory of Biomedical Nanomaterials (IMS/VAST in
Hanoi), on fabrication and characterization of nanovectors for the
disease of cancer. The first part deals with magnetite (Fe3O4)
nanoparticles (MNPs) based nanoconjugates, functionalized by coating
with several polymers as well as loaded with a drug of curcumin. The
used MNPs were obtained by coprecipitation, exhibited spherical shape of
diameter of 15-20 nm, saturation magnetization of Ms ~ 65-70 emu/g. The
coating polymers were acrylic acid (PAA), chitosan (CS) and Alginate
(Alg) which were confirmed using the infrared (FTIR) spectra. Magnetic
Inductive Heating (MIH) measurements demonstrated that the fabricated
MNPs-based conjugates exhibited quite high heating performance,
perspective for hyperthermia application. The application of Fe3O4@PAA
for in-vivo hyperthermia treatment of cancer incubated on mice will be
shown. As for imaging application, the Fe3O4@CS@Cur was used to
demonstrate a dual possibilities, fluorescence and magnetic resonance,
of monitoring cell penetration by macrophage. In the second part, we
show a recent study on targeted delivery systems of
paclitaxel/doxorubicin/curcumin-loaded copolymer/polymer nanoparticles,
which were prepared by a modified solvent extraction/evaporation
technique and decorated by folic acid. The obtained spherical
nanoparticles were negatively charged with a zeta potential of about −
30 mV with the size around 50 nm and a narrow size distribution. The
targeting effect of anticancer-drugs nanoparticles with folate
decoration was investigated in vitro by the uptake in cancer cell lines
and in nude mouse. The results indicate that the targeted
paclitaxel/doxorubicin/curcumin-loaded copolymer/polymer nanoparticles
are successful anticancer-targeted drug delivery system for effective
cancer chemotherapy.
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