In Vivo Hahn Spin-Echo Decay (Hahn-T2) Observation of Regional Changes in the Time Course of Oleic Acid Lung Injury
We studied the time course of changes in the Hahn spin-echo decay (Hahn-T2
) in lungs of spontaneously breath-ing living rats at 1 hour, 3 hours, and 7 days following
oleic acid injection. Motion artifacts were minimized by
using the motion-insensitive interleaved rapid line scan
(ILS) imaging technique. Prior to injury, the lungs exhib-ited two resolvable exponential Hahn-T2
components.
One and 3 hours after injury the decay showed a region-ally nonuniform behavior, which was fit with one, two, or
three exponential components. The short and medium
components increased at 1 and 3 hours after injection.
The third, much longer, component is probably due to
intraalveolar pulmonary edema. After 7 days the Hahn
decay was similar to that observed before injury, proba-bly reflecting resolution of the edema. Our data suggest
that Hahn-T2measurements can be used to characterize
the time course and regional distribution of lung injury
in living animals. J. Magn. Reson. Imaging 2000;11:
215–222.
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